The vitamin K-dependent γ-glutamyl carboxylase gene contains a TATA-less promoter with a novel upstream regulatory element Running title: A Novel Element Regulates the Carboxylase Promoter
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منابع مشابه
HEMOSTASIS, THROMBOSIS, AND VASCULAR BIOLOGY The vitamin K–dependent -glutamyl carboxylase gene contains a TATA-less promoter with a novel upstream regulatory element
The expression of the vitamin K–dependent -glutamyl carboxylase gene in liver is developmentally regulated. Since the gene product catalyzes an essential posttranslational modification of the vitamin K–dependent blood coagulation proteins, the regulation of carboxylase expression is critical for hemostasis. We analyzed the activity of the rat carboxylase gene 5 -regulatory DNA sequences in rat ...
متن کاملThe vitamin K-dependent gamma-glutamyl carboxylase gene contains a TATA-less promoter with a novel upstream regulatory element.
The expression of the vitamin K-dependent gamma-glutamyl carboxylase gene in liver is developmentally regulated. Since the gene product catalyzes an essential post-translational modification of the vitamin K-dependent blood coagulation proteins, the regulation of carboxylase expression is critical for hemostasis. We analyzed the activity of the rat carboxylase gene 5'-regulatory DNA sequences i...
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Transcription of the Saccharomyces cerevisiae his3 gene requires an upstream promoter element and a TATA element. A strain containing his3-delta 13, an allele which deletes the upstream promoter element but contains the TATA box and intact structural gene, fails to express the gene and consequently is unable to grow in medium lacking histidine. In this paper we characterize His+ revertants of h...
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Two promoter elements, the TATA element and initiator (Inr), are capable of directing specific transcription initiation of protein-encoding genes by RNA polymerase II (RNAPII). Although binding to the TATA element by the TATA-binding protein (TBP) has been shown to be the initial recognition step in transcription complex formation in vitro, the mechanism through which the basal machinery assemb...
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تاریخ انتشار 2003